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Cited By Published on Apr 24, in Clean-soil Air Water 1. Damian Pietrzak , J. Kania 4 Estimated H-index: 4. Estimated H-index: 3. Chronic brain toxicity response of juvenile Chinese rare minnows Gobiocypris rarus to the neonicotinoid insecticides imidacloprid and nitenpyram. Abstract Imidacloprid and nitenpyram are widely used neonicotinoid pesticides worldwide and were observed to adversely affect non-target aquatic organisms. In this study, the toxic effect of imidacloprid and nitenpyram on the brain of juvenile Chinese rare minnows Gobiocypris rarus was investigated by determining the oxidative stress, 8-hydroxydeoxyguanosine 8-OHdG content and acetylcholinesterase AChE activity.

The superoxide dismutase SOD activities did not significantly change af Resistance to cycloxaprid in Laodelphax striatellus is associated with altered expression of nicotinic acetylcholine receptor subunits. Yueliang Zhang 8 Estimated H-index: 8. John E. Casida 79 Estimated H-index: Neonicotinoids neonics are remarkably effective as plant systemics to control sucking insects and for flea control on dogs and cats. The nitroimines imidacloprid, clothianidin, thiamethoxam, and dinotefuran are the leaders among the seven commercial neonics that also include the nitromethylene nitenpyram, the nitromethylene-derived cycloxaprid, and the cyanoimines acetamiprid and thiacloprid.

Honey bees are highly sensitive to the nitroimines and nitromethylenes, but the cyanoimines are less t Functional Derivatives of Ethyl 4- Chloromethyl -2,6-dimethylpyridinecarboxylate. Dikusar 8 Estimated H-index: 8. Estimated H-index: 7. Estimated H-index: The condensation of ethyl 4- chloromethyl -2,6-dimethylpyridinecarboxylate with substituted phenols in ethanol in the presence of potassium carbonate afforded the corresponding aryl pyridinylmethyl ethers.

Nicotinoid insecticides and the nicotinic acetylcholine receptor

Analogous condensation with substituted anilines gave 2-aryl-4,6-dimethyl-1,2-dihydropyrrolo[3,4-c]- pyridinones. Esters containing 1,2-azole fragments were synthesized by acylation of hydroxymethylsubstituted ethers with 5-arylisoxazole- and 4,5-dichloroisothiazolecarbonyl chlorid Synthesis and identification of nicotinium sulfate 3- 1-methylpyrrolidinyl pyridine:H2SO4 from tobacco-extracted nicotine: A protic ionic liquid and biocompatible catalyst for selective acetylation of amines.

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Fatemeh Tamaddon 17 Estimated H-index: Europe PMC requires Javascript to function effectively. Recent Activity. ABT has considerable nicotinic acetylcholine receptor AChR subtype specificity which might carry over to the chloropyridinyl insecticides. This study considers nine IMI analogues for selectivity in binding to immuno-isolated alpha1, alpha3 and alpha7 containing nicotinic AChRs and to purported alpha4beta2 nicotinic AChRs.

With immuno-isolated alpha3 nicotinic AChRs, the tetrahydropyrimidine analogues of IMI with imine or nitromethylene substituents are fold less active than - -nicotine. The structure-activity profile with alpha3 nicotinic AChRs from binding assays is faithfully reproduced in agonist potency as induction of 86rubidium ion efflux in intact cells. The commercial insecticides IMI, acetamiprid and nitenpyram have low to moderate potency at the alpha3 and purported alpha4beta2 nicotinic AChRs and are essentially inactive at alpha1 and alpha7 nicotinic AChRs.

In conclusion, the toxicity of the analogues and metabolites of nicotinoid insecticides in mammals may involve action at multiple receptor subtypes with selectivity conferred by minor structural changes.

Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor | I. Yamamoto | Springer

The snippet could not be located in the article text. This may be because the snippet appears in a figure legend, contains special characters or spans different sections of the article. Br J Pharmacol. PMID: Find articles by Motohiro Tomizawa. Find articles by John E Casida.

Copyright , Nature Publishing Group. This article has been cited by other articles in PMC. Open in a separate window. Figure 1. Figure 2.

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Methods Chemicals Structures and abbreviations for the nicotinoids studied are given in Figure 2. Radioligand binding Supernatants from Torpedo electric organ or SH-SY5Y cell preparations were used for immuno-isolation of receptor subtypes Anand et al. Toxicity Male albino Swiss-Webster mice 20—25 g were treated i. Table 1. Figure 3. Figure 4. Figure 5.

Introduction to Nicotinic Acetylcholine Receptors Part 1

Figure 6. Figure 7. Toxicity The i. Figure 8. Acknowledgments The project described was supported by Grant Nos. FEBS Lett. Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain Res. Epibatidine, a potent analgetic and nicotinic agonist. Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Imidacloprid actions on insect neuronal acetylcholine receptors.


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Interaction of imidacloprid metabolites and analogs with the nicotinic acetylcholine receptor of mouse brain in relation to toxicity. CHEN D. Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit composition. Nicotinic acetylcholine receptors of the central nervous system of Drosophila. Neuronal nicotinic receptors in the locust Locusta migratoria — cloning and expression.

Neuronal nicotinic acetylcholine receptors as targets for drug discovery. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Sensitive nicotinic and mixed nicotinic-muscarinic receptors in insect neurosecretory cells. Labelled Compounds Radiopharmaceut. Nicotinic acetylcholine receptors in health and disease. High affinity binding of [ 3 H]imidacloprid in the insect acetylcholine receptor. LIU M. Relevance of [ 3 H]imidacloprid binding site in house fly head acetylcholine receptor to insecticidal activity of 2-nitromethylene- and 2-nitroimino-imidazolidines.

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Imidacloprid binding site in Musca nicotinic acetylcholine receptor: interactions with physostigmine and a variety of nicotinic agonists with chloropyridyl and chlorothiazolyl substituents. Pharmacological distinctions between functional nicotinic acetylcholine receptors on the PC12 rat pheochromocytoma and the TE human medulloblastoma. Characterization of nicotinic acetylcholine receptors expressed by cells of the SH-SY5Y human neuroblastoma clonal line.

Cell Neurosci. Efficacy of plant metabolites of imidacloprid against Myzus persicae and Aphis gossypii Homoptera : Aphididae Pestic. PENG X. The diversity of neuronal nicotinic acetylcholine receptors. Novel neonicotinoid-agarose affinity column for Drosophila and Musca nicotinic acetylcholine receptors. Structure and function of insect nicotinic acetylcholine receptors studied with nicotinoid insecticide affinity probes Nicotinoid insecticides and the nicotinic acetylcholine receptor Tokyo: Springer-Verlag; eds Yamamoto, I.


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Pharmacological effects of imidacloprid and its related compounds on the nicotinic acetylcholine receptor with its ion channel from the Torpedo electric organ.