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Thus, Ames et al. There is increasing recognition that certain chemicals can cause mutations through other types of mechanisms. Ferguson and Baguley 3, 4 reviewed the inhibition of topoisomerase enzymes as a mutagenicity mechanism see DNA Topology.


Turner and Denny 5 reviewed the mutagenic properties of ligands that can bind noncovalently to the minor groove of DNA and span a range of DNA sequence selectivities. Kunz et al. Next post: Mutagenesis Molecular Biology. Previous post: Multivalents Molecular Biology. If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

Molecular Biology of Mutagens and Carcinogens

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Mechanisms of DNA-reactive and epigenetic chemical carcinogens: applications to carcinogenicity testing and risk assessment. Williams a. This article is part of the themed collection: Recent Review Articles. You have access to this article.